AFAIK it all boils down to the fact that during embryonal development our cells, which at that point were just a blob of undifferentiated autonomous chemical machines, somehow managed to unanimously agree upon the cardinal directions (up-down, left-right, front-back) for future development - and thanks to this, we don’t have toes growing out of our ears.
Pass the joint, bud.
Heh, “bud”
That’s what SHE said! Wait. What?
It’s not that incredible, considering we can get cysts full of teeth and hair inside the body
How do I unread this
Oh yes, teratomes are not fun. But thankfully they are comparably rare.
Imagine if you suddenly sprouted a tumor with functional tastebuds in your colon
“So what brings you into the doctors office today?”
“Well for some reason everything I eat ends up tasting like shit.”
Ugh and I thought burping after having Fish Oil pills was bad…
Wonder if we could use that phenomena to regenerate teeth in a lab for replacements and dentures.
Probably no different than stem cell stuff
I mean, that’s what dna is for. These machines aren’t operating blindly (or even “cooperating” or agreeing on anything, really). They’re following the code that makes up who we are.
Yeah but it’s crazy how any given cell knows where in the body it is, somehow.
They don’t so much know where they are as much as they’re just interacting with what’s there in the way they were made to, which was all put there due to the DNA to function as a whole.
And to be clear, it’s all still amazing, just in a different way. Here’s Kurzgesagt video that helps explain how these cells “communicate” to do things like put a body together in the right order.
Here is an alternative Piped link(s): https://piped.video/watch?v=TYPFenJQciw
Piped is a privacy-respecting open-source alternative frontend to YouTube.
I’m open-source, check me out at GitHub.
Those who don’t usually don’t make it far.
Survivorship bias
That’s not it.
Someone was probably born with toes on their head in the past and life didn’t go so well that they could have children that also survived. This is why our DNA doesn’t have instructions for growing toes on our head.
Sure, but every cell has the same DNA. Yet some “decide” to “agree” on making toenails, while others differentiate into eyes.
If an embryo decides to split in two, and then sends out the marker that “this is the right side” and it’s too close to the other embro, there will be a set of identical twins, but one will have the heart on the right side, appendix on the opposite side etc. This needs to be known if the “mirrored” person has a colonoscopy, since the colon is folded the opposite direction.
The toes are the powerhouse of the foot
That’s the core of evolution: Beings with unfavorable features simply don’t make it.
Too bad evolution is blind, and now our windpipes and digestive tracts cross over. It works, but it would have been nice if choking wasn’t a thing.
Other examples of interesting (sometimes called ‘unintelligent’) evolution might be how we walk upright, leading to complications with childbirth and back pain, blindspots because of our optical nerve, and or that recurrent nerve that does a random U-turn.
Evolution is basically millions of years of patches without ever getting a rebuild form the ground up. It’s mostly ok, but some bugs stick around
Interestingly, the recurrent laryngeal nerve is looped around that way because the structure of the nerve grows in before the structures of the aorta and other large vessels fully grow in and orient into their correct position, so the nerve ends up looping around them.
This is just based on an offhand comment from a lecturer during a practical session during my time studying animal management in college, not directly from a biology lecturer so citation needed, but apparently rabbits don’t have a combined windpipe/digestive tract and it means that a blocked nose can kill them. So even if choking wasn’t a thing we’d have to worry about something blocking our noses and suffocating us.
Oh that’s actually a good point, so there are upsides as well.
Movies would also look really silly when someone would get killed by having their nose pinched closed
We just walkin’ with a couple billion years of biotech debt in us.
I always thought that was a poor design. Aliens likely would find that disgusting.
What interests me is that I believe all warm blooded animals also share this trait. Not certain that is true but if so, wouldn’t that mean it evolved in a very early period?
Also what I find interesting is that the layout of humans to most animals is the same. A head with eyes then nose then mouth among with the brain behind it. Most of the organs are in similar locations. It seems strange that there would not be more variety.
That 85% of DNA that apparently does nothing? Commented out.
It has a small function. A random gamma ray decides to absorb into DNA? Well, 85% chance it won’t matter.
My understanding is that on average a human will make malignant cell about once a year, but the other anti-cancer systems of the body deal with it. People that develop cancer had one of those cells escape the system. Without introns this would be a much more frequent event.
Similar idea: at work we were sintering metal powders together in a vacuum chamber, but had oxygen diffuse into the metal about twice as much as our limit to keep it strong. So the lead researcher took titanium powder that weighed a little more than twice what our work part weighed and put it in the chamber, and the oxygen level dropped to about half in our parts. After that he started making three parts at a time to keep oxygen levels down.
It’s not a reason for developing this way, but introns are great for familial testing. They don’t need to be preserved so they’re changing all the time. If we didn’t have introns, familial testing would have to be done by looking at several DNA or protein types. Blood type, what D2 receptor phenotype. What MTHFR phenotype, etc.
Sorry for long post but I love this topic: in all primates non-coding DNA, there’s the gene that makes vitamin C. Most mammals make their own, except primates and Guinea pigs. In primates, the vitamin C gene is broken at the same location. So, the chances of multiple species of primates developing this mutation at the same place is very low. They’d all have to develop this mutation at the same place and thrive over the other members of the species, and become the dominant phenotype, and all offspring consume enough vitamin C in their diet to thrive also. Every single primate!
Instead, it’s much more plausible that one primate or primate ancestor develop this mutation in an area where the food sources had plenty of vitamin C, and a population reduction caused this ancestor primate to be the sole ancestor of the remaining primates, which then evolved to become monkeys, apes, and humans.
The Guinea pig vitamin C mutation that causes it to not work? It’s in a different location than the primate mutation.
Edit: apparently some primates can make vitamin C. But most can’t, and the ones the can’t, the gene is broken at the same place.
I recognize several of these words.
(Jk thats very detailed and interesting! You seem really passionate about your work/study!)
I can’t comment on anyone with toes out of their ears, but I’ve seen a lot people with their butt where their face is. Or at least it would appear so, as a lot of shit seems to come out of the hole in their face.
All jokes aside, nice shower thought though!
In science that is called symmetry breaking (going from a homogeneous blob to left right something) and a very active topic of Research.
Gravity is what makes this happen. Guess what probably is a concern in space?
You know that we’ve gestated various animals in weightless conditions on the ISS, yes? They look normal.
We have? Do you have a source for that? That would be amazing. :)
Toe ears?
You JUST realized that. 🙄
I mean, there are a lot of things that we’ve always “known”, but one day you just really thing about it and realize how fucking wild it is.
That’s why there is an entire community for shower thoughts: because people sometimes get these sudden realizations. But honestly, you got me - I realized it a few days ago and only got around to post it “now”.
