The sweetener is aspartame
it’s always aspartame
Hero.
King.
The “solution” was diazepam.
1, it’s aspartame
2, Mice aren’t humans, and routinely, things that happen in mice do not happen in humans. It is not at all indicative of anything and can really only be used as a hint better than nothing for looking into similar effects in humans.
You don’t need to change your diet, and you certainly don’t need to replace it with sugar.
*But drinking a glass of water from time to time won’t kill you either.
Comment paid for Big Aspartame.
Deep Sugar take
I see the Nutrasweet Lobbyists Association is here too!
Big aspertame made that account 6 months ago, posted 1300 unrelated comments, just for this one moment…
The long con!
How much is Big Sugar paying you?
Not enough :(
Considering the patent was held by Monsanto, and all the decades of concerns have been raised by independent researchers but shut down by lobbying…
Well, I mean, who can you trust to not hide that they’re making poison if not Monsanto?
I am a relatively recent transplant from the red place, I can tell I ain’t in Kansas anymore, actual good information being up voted so cool.
Aspartame is, because of all the claims against it, the single most studied food substance known, and it seems to somehow keep coming okay. There are a lot of studies with really bad methods that were a smear job attempt but science doing what it does they were labeled for what they are and disregarded. Is it possible to be allergic and a reaction to be anxiety sure, but that is not on the food.
Not to mention that the gene pool of these lab mice is super small. Source: my brother is a PhD biochemist and lectured me often on this shit when I said, “hey, look at this study!”
The small gene pool is done on purpose. The mice are supposed to be as close to clones as possible so that you can have control populations and be confident that the results weren’t affected by certain genes and mutations in the test population.
The size of the gene pool isn’t really an issue though because they can be bred however it’s required for tests. They have quite a lot of control over the genetics of those lab mice.
Testing for a cure for diabetes? They can produce mice that are almost guaranteed to develop diabetes that you can then try to cure.
Such a small groups are fine for initial investigation, they have enough of a size to be acceptable statistically for most of the performed studies. I don’t think they’d get approval from ethical committee overseeing animal experiments without initial study like this to conduct something on very high groups.
Guarantee the study also states that you have to consume an ungodly amount of it too…
News reports grab on to stuff like this all the time. Like what they did with safrole.
The article actually states how much. 15% of the daily recommended amount.
I stand corrected! That’s a ridiculously small amount!
Oh, good! I thought it was the rapidly declining state of the world.
Sugar shills and don’t touch my diet coke ppl in this thread doing Spidermanpointing.jpg
Stevia crew represent.
Stevia is great, but I really love monk fruit. No licorice root like aftertaste. I have more of a problem with the carcinogenic preservative they always pair with aspartame personally.
I don’t mind monk fruit all that much but it definitely has its own particular flavour which can require adjustment too. Bit of its own aftertaste as well.
The only good Natural Low calorie sweetner
J prefers that munkmunk sauce
The control was plain water. That seems like the sort of methodological flaw that would preclude a study from publication in a journal like PNAS.
Can you elaborate why do you think that water is improper control?
They’re providing a sweetener at all times. That alone would have some affect, so I’d think you’d want another sweetenere like sucrose, glucose, some other artificial sweetener, in addition to a water treatment. Alternatively, a dose response could be informative. They did have different doses of aspartame, but in both groups of mice (male and female), the dose response was opposite what you’d expect; the lower dose had a larger effect.
Mice lie, monkeys exaggurate.
This is a study on a small number of mice using a measure of anxiety which does not directly map to humans. Using mice for a study like this is fine for a pilot study but this has not clinical significance and can be safely ignored by the scientific press as well as the public. When we see a long term study which is double blinded in humans with reasonable doses, good controls, and hopefully some sort of mechanism of action then we can pay attention. Until then, aspartame has been linked to everything under the sun and yet nothing has been shown to be meaningful yet. It is one of the most well studied substances in the human diet and it seems to be at the very least mostly fine. Worry about lead in your water before you worry about this.
When we see a long term study which is double blinded in humans
For several generations like the this one this would be 60 years minimum. Basically can’t be done.
I see what you are saying but I disagree. The changes that we would consider important for aspartame should happen over a reasonable period of time. If it takes 100 years to have an impact then we probably don’t care because most people won’t live that long. What we care about is whether it has an impact over meaningful lengths of time in a human life, say over a decade or two.
If I have tobacco every day for a year will I have cancer? Unlikely. But if I give a large number of people who are well randomised tobacco or tobacco substitute I will see changes in their outcomes in a short time, even as little as a year.
So for aspartame, we already know it is not a massive signal. If it were then people who find the taste acrid would be better off than those who do not. But is there a possible issue there? Sure, it is possible, but it will very likely be a mild issue over a long time at a high dose, not at small doses over a short time, so this study design is not fit for purpose and it should be ignored.
reasonable period of time.
That misses the entire point of studying multi generational effects.
we probably don’t care because most people won’t live that long.
Again, misses the entire point of studying multi generational effects.
meaningful lengths of time in a human life, say over a decade or two.
Again.
even as little as a year.
Again.
not a massive signal.
Again.
will very likely be a mild issue over a long time at a high dose, not at small doses over a short time,
That’s the whole point of the study, to do a low dose over a super long time over generations. Not a high/med dose over a short time.
not at small doses over a short time,
Again, misses the entire point of studying multi generational effects.
so this study design is not fit for purpose and it should be ignored.
And a final: Again, misses the entire point of studying multi generational effects.
I think I’m going to say cheers since sorry to say you missed the entire point, objective, and goal of the study and you want to study something else entirely. Cheers.
I think I’ll pass on the opinion of someone who can’t spell “exaggerate.”
Cool, fair enough, I do have a little trouble with spelling and that is fine. Of course it could be software, learning difficulties, or just a bad day, but feel free to discard all the words I spelled correctly. Also, if you are in the US including the full stop in your quotation is typical but in the rest of the world you would keep the punctuation outside the quotes unless it is what you are quoting, otherwise the sentence doesn’t have its own full stop.
as someone with dyslexia, i agree, honestly if it can be understood and its in a forum then why should it matter, its not like you’ve written a medical journal or legal binding letter
deleted by creator
Cool, take the low hanging ad hom, instead of actually interacting with the statement. Also it’s “exaggerate”.
So my problems are because my mom is addicted to diet coke? It’s all adding up!
deleted by creator
What problems do you have?
Wow, lots of astroturfed opinions defending aspartame.
Glad to see the “everything positive is astroturfing” clowns made their way over from reddit, too.
The important thing is you found a way to feel superior to both without needing to voice your opinion.
Any evidence to back up the assertion that they are shills, or is it just an empty ad hominem because you can’t address an actual point?
To be clear, fuck that aspartame garbage.
Any reason you think I should care about your opinion on anything, at all?
But to address your question, maybe it has something to do with walls of replies that read like a PR script. Use your head for more than memes.
So, no, you have no evidence to back up the assertion, it’s just how you feel.
Use your head for more than memes.
If blaming me for your inability to back up your claims is your definition “using your head” I’m happy to continue going through life without doing so.
You do you, bro/chick.
Yes, I definitely plan to do that. Thanks for the permission. Lol
I mean, if the choice is between sugar and aspartame… seems like an easy choice to make - the science should speak for itself
I’ve been dabbling with stevia but last time I put to packets in my tea and it was apparently too much and I did not feel well after
Choice should be sugar, just a lot less of it
That’s my take, but It took overloading on sugar to get me there. My grandma made southern sweet tea as she called it. It was like sugar water lol. We went out to eat 10 years ago and I was thirsty, had 3 large glasses of sweet tea before the food came, spent most of the time in the bathroom and could no longer stand sugary drinks. Unsweet tea, or half as much simple syrup if I can choose.
I tried stevia, also, and it’s too sweet.
In my research to find a substitute for mom’s sugar intake, Stevia came down to being the safest and most reliable, albeit not the best flavor substitute, necessarily.
And avoid Erythritol above all else.
When a sample of mice were given free access to water dosed with aspartame equivalent to 15 percent of the FDA’s recommended maximum daily amount for humans, they generally displayed more anxious behavior in specially designed mood tests.
What’s truly surprising is the effects could be seen in the animals’ offspring, for up to two generations.
We know that when it’s consumed, aspartame splits into aspartic acid, phenylalanine, and methanol, which can all affect the central nervous system. There have already been question marks over potentially adverse reactions to the sweetener in some people.
People need to get in touch with their groceries. I’m lucky that I have really strong reactions to food because it’s obvious what affects me or not. I become a full on grouchy interrogator when I have aspertame, same with MSG but that’s more of an accumulation thing.
Donald Rumsfeld and the Strange History of Aspartame
Edit: I think he came back from the dead to downvote this.
Well, shit.
And it still is too.
I wonder if the inherited anxious behaviour is through epigenetics or learned from the parents?
My theory, and again it’s just a theory, anxiousness from things you eat is your body stressing out that you can’t process it or something. Of course, it needs more studies, but you could inherit slight allergies and the learned behavior.
My understanding is your body processes aspartame just fine. It’s just much sweeter than cane sugar so you have to use less than a calorie to achieve the same effect as a hundred calories of cane sugar.
That might be true? I just know how it affects me, Human studies are just people like you and me giving their feedback as to whether or not something gives them symptoms or not. I definitely get that angst with aspertame. So, even if it’s a small percentage that are effected by it, I would be included in that small percentage.
As bad as all the sugar substitutes taste I honestly don’t get how they ever caught on, starting at saccharine and on down the line. Stevia, aspartame, just taste… wrong. Minimally refined cane sugar or honey are the only way to go.
