Y’all is the opposite of offensive for trans people. I lived in the south for a while, and I now use y’all specifically to be inclusive. I wouldn’t say “you guys” is offensive to trans women, but I would say for me and likely other trans women it briefly brings to mind being misgendered in the past, so I would call it a small kindness to ube as gender neutral as possible.
This is like the house of my dreams. Not my daydreams, my actual sleeping dreams, where each room is super weird and I can never find my way back to the one room I need to be in.