A two+ hour drive would really take it out of me. I would often have to stop and have a 10 minute nap.
I’ve found meds have really helped, I still feel tired, but I don’t have to sleep afterwards or take naps.
Same with riding motorbike, but double. I think it’s the intense concentration for long periods of time.
That’s never really been an issue to me, thanks to unlimited Autobahn. I can barely focus at speeds below 130, so I always went for the fast lane.