Research from UC Berkeley indicates that ongoing stress caused by protein aggregation is leading to the death of brain cells. Numerous neurodegenerative conditions, including Alzheimer's and Parkinson's, involve the buildup of protein clusters, known as aggregates, within the brain. This phenomenon

This research indicates that in neurodegenerative conditions ongoing stress caused by protein aggregation is leading to the death of brain cells. This reports a ubiquitin-dependent mechanism that silences the cellular response to stress. Stress response silencing was found to sustain cell survival even if stress resolution failed.

https://www.nature.com/articles/s41586-023-06985-7 (open access)